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Paper   IPM / Physic / 8770
School of Physics
  Title:   Analytical and Numerical Studies of Sequence Dependence of Passage Times for Translocation of Heterobiopolymers through Nanopores
  Author(s): 
1.  R. H. Abdolvahab
2.  F. Roshani
3.  A. Nourmohammad
4.  M. Sahimi
5.  M. R. Rahimi Tabar
  Status:   Published
  Journal: J. Chem. Phys.
  Vol.:  129
  Year:  2008
  Pages:   235102
  Supported by:  IPM
  Abstract:
DNA and other biomaterials that undergo translocation in small pores con- sist of stacks of distinct bases. We consider chaperone-assisted translocation of biopolymers with two distinct monomers or bases, with the size of the chaperones being λsigma, where σ is a monomer's size. A master equation is used, together with detailed-balanced condition, as well as Monte Carlo sim- ulation, to study the problem. Analytical results for certain values of λ and the biopolymer's configuration, as well as numerical values for biopolymers of size 100-900 and several λ are presented. The results indicate sensitive dependence of the statistics of the translocation time on the biopolymer's composition. It is also shown that measurements of the first two moments of the biopolymer's first-passage times provide information on its length and ordering. This Paper has been selected for the January 1, 2009 issue of Virtual Journal of Biological Physics Research.

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