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IPM
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“School of Nano-Sciences”

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Paper   IPM / Nano-Sciences / 15461
School of Nano Science
  Title:   Interaction of low frequency external electric fields and pancreatic β-cell: a mathematical modeling approach to identify the influence of excitation parameters
  Author(s): 
1.  Sajjad Farrashi
2.  Pezhman Sasanpour
3.  Hashem Rafii-Tabar
  Status:   Published
  Journal: Int. J. of Radiation Biology
  No.:  11
  Vol.:  94
  Year:  2018
  Pages:   1038
  Publisher(s):   Taylor & Francis Group
  Supported by:  IPM
  Abstract:
Purpose: Although the effect of electromagnetic fields on biological systems has attracted attraction in recent years, there has not been any conclusive result concerning the effects of interaction and the underlying mechanisms involved. Besides the complexity of biological systems, the parameters of the applied electromagnetic field have not been estimated in most of the experiments. Materials and Methods: In this study, we have used computational approach in order to find the excitation parameters of an external electric field which produces sensible effects in the function of insulin secretory machinery, whose failure triggers the diabetes disease. A mathematical model of the human b-cell has been used and the effects of external electric fields with different amplitudes, frequencies and wave shapes have been studied. Results: The results from our simulations show that the external electric field can influence the membrane electrical activity and perhaps the insulin secretion when its amplitude exceeds a threshold value. Furthermore, our simulations reveal that different waveforms have distinct effects on the b-cell membrane electrical activity and the characteristic features of the excitation like frequency would change the interaction mechanism. Conclusion: The results could help the researchers to investigate the possible role of the environmental electromagnetic fields on the promotion of diabetes disease.


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