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IPM
30
YEARS OLD

“School of Nano-Sciences”

Paper   IPM / Nano-Sciences / 14455
   School of Nano Science
  Title: Are deformed neurons electrophysiologically altered? A simulation study
  Author(s):
1 . Tahereh Takieh
2 . Sohrab Shahzadi
3 . Hashem Rafii Tabar
4 . Pezhman Sasanpour
  Status: Published
  Journal: Current App. Phys.
  No.: 10
  Vol.: 16
  Year: 2016
  Pages: 1413-1417
  Publisher(s): Elsevier B.V.
  Supported by: IPM
  Abstract:
The electrophysiological outcome of neuron deformation is studied. This study is based on modeling the propagation of action potentials in a neuron with different deformed segments subject to an external mechanical compression. The proposed model is based on modified cable equation incorporating geometry variations. The study is performed for different degrees and number of deformations of the axon structure. The results of simulation show that the propagation speed, the refractory period, and the action potential broadening are all directly affected by variations in the geometry.

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