Part I: Brain Imaging
Optical imaging offers a non-invasive, safe and low-cost tool for real-time biomedical health monitoring, supports a broad range of applications toward measuring both the functional and morphological states of the neurovascular system. Using new optical techniques such as functional near-infrared spectroscopy (fNIRS) both the slow-hemodynamics and fast-neuronal signals can be monitored not offered by any other available single imaging techniques. However, to date the realization of this potential to employ these systems in real-time wireless biomedical imaging applications has not been materialized enough with current commercial devices due to the high-power consumption and size issues and their limited low-deep and spatial resolution. A miniaturized, smart, auto-powered, wireless system has been introduced for long-term optical imaging applications. This novel flexible and biocompatible system includes a power-harvesting block, light sources, SiAPDs, ADCs, signal processing unit and an low-power RF transceiver, all integrated on-chip using standard CMOS technology. The proposed power-harvesting block, maintains the required power using a hybrid auto-powering technique. The miniaturized smart wireless patch monitors the neurovascular dynamics continuously and sends data to a wireless station (cell-phone/PC). An array of the proposed systems can be also applied in a wireless body area networked sensors by interconnecting different patches attached to the different locations of the body. The low-power consumption of the system makes it a proper candidate for long-term wireless bio-imaging and body area networked sensors. It provides a novel HMI technique and can also be used as an integrated, miniaturized, plug-and-play, non-invasive, portable and real-time tool for whole-body monitoring.
Part II: Wearable and Implantable Smart Theranostics
Progress in advanced materials and nanotechnology paved the way for the realization of the novel miniaturized smart devices for real-time diagnostics and therapeutic applications. We have introduced and implemented a new smart contact lens including biosensors, drug-delivery and in-situ signal processing for the diagnostics and treatment of ocular disease (diabetics, cataract, etc.). This flexible, biocompatible and miniaturizes device was wirelessly powered using a smart glass providing the enough power for the ocular micro-electronics and the biosensors. It can transmit the detected ocular signals to the smart eyeglass and also smartphone for future processing and diagnostics applications. A miniaturized ocular drug-delivery system was also implemented to release the drug automatically or on-demand using smartphone or by user voice command. The efficient wireless power transfer technique and the elaborated miniaturized microelectronic integrated circuit implemented using CMOS and nano-electromechanical (NEMS) technologies introduces a new alternative platform for future diagnostics, treatment, healthcare and human-machine interface (HMI) applications.
School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM),
Opposite the ARAJ, Artesh Highway, Tehran, Iran