| Friday 19 April 2024 | |
| Events for day: Thursday 28 November 2019 |
| 10:00 - 11:00 Weekly Seminar Quantification of the effect of metabolism on the epigenome of human cancers School BIOLOGICAL SCIENCES Altered DNA and histone methylation are common in cancer and often considered early events in tumorigenesis. However, the sources of heterogeneity of DNA methylation among tumors remain poorly defined. We previously showed that the status of methionine metabolism is sufficient to determine levels of histone methylation by modulating levels of metabolites in the methionine cycle. Modulation of methionine in diet led to changes in metabolism and histone methylation in the liver. Here we capitalize on the availability of multi-platform data on thousands of human tumors to build integrative models of DNA methylation. We quantify the contribution ... |