Wednesday 8 April 2020 |

Events for day: Thursday 19 September 2019 |

09:30 - 10:30 Weekly SeminarQuantitative flux coupling analysis School BIOLOGICAL SCIENCES Flux coupling analysis (FCA) aims to describe the functional dependencies among reactions in a metabolic network. Currently studied coupling relations are qualitative in the sense that they identify pairs of reactions for which the activity of one reaction necessitates the activity of the other one, but without giving any numerical bounds relating the possible activity rates. The potential applications of FCA are heavily investigated, however, apart from some trivial cases, there is no clue of what bottleneck in the metabolic network causes each dependency. In this talk, we introduce a quantitative approach to the same flux coupling problem n ... 11:00 - 12:00 Weekly SeminarMetabolic network reductions School BIOLOGICAL SCIENCES Genome-scale metabolic networks are exceptionally huge, and even efficient algorithms can take a while to run because of the sheer size of the problem instances. To address this problem, metabolic network reductions can substantially reduce the overwhelming size of the problem instances at hand. We begin by formulating some reasonable axioms defining what it means for a metabolic network reduction to be “canonical,” which conceptually enforces reversibility without loss of any information on the feasible flux distributions. Then, we start to search for an efficient way to deduce some of the attributes of the original network from the reduced ... |