IPM Calendar 
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Events for day: Thursday 02 May 2019    
           10:00 - 11:00     Weekly Seminar
On using gene genealogies to find trait-influencing variants

School
BIOLOGICAL SCIENCES

We propose an approach to fine-mapping the genomic location of a trait-influencing variant. Through simulation, we investigate the properties of the approach for binary and quantitative disease traits in diploid individuals that have been sampled for a case-control study. For genetically heterogeneous traits that are influenced by many rare variants, we find that the approach can be improved by reclassifying case haplotypes according to their inferred carrier status. We show that such reclassification can help in localizing trait variants across the targeted genomic region. ...