Tuesday 23 April 2024 |
Events for day: Thursday 10 January 2019 |
10:00 - 11:00 Weekly Seminar Mathematical Modeling and Analysis of Gene Expression to Understand Phenotypic Heterogeneity and the Response of Methylobacterium extorquens to Formaldehyde Toxicity School BIOLOGICAL SCIENCES Methylobacterium extorquens is a facultative methylotrophic bacterium that lives on plant leaves. As part of the natural oxidation pathway of methanol secreted from the leaves, formaldehyde is generated. Experiments have shown there is phenotypic heterogeneity in tolerance to formaldehyde, and this heterogeneity varies continuously. Exposing M. extorquens to a high concentration (4 mM) of formaldehyde changed the distribution of tolerance to formaldehyde. In the first part of this work, we introduced a mathematical model to investigate the processes involved in the change of the tolerance distribution. The model suggests there is an absolute ... |