|Monday 21 May 2018|
|Events for day: Thursday 21 December 2017|
| 10:00 - 11:00 Seminar|
Identification and characterization of novel upstream regulators of the Hippo signaling pathway
The evolutionarily conserved Hippo signaling pathway is a major determinant of growth control and organ size. The co-transcription factors YAP/TAZ are downstream effectors of the Hippo pathway that regulate vital processes like cell proliferation, cell migration, apoptosis, stem cell self-renewal and differentiation. YAP/TAZ are regulated by the core Ser/Thr kinases of the Hippo pathway MST1/2 and LATS1/2. Upon activation, MST1/2 in association with the adaptor protein SAV, phosphorylate and activate the downstream kinases LATS1/2. In turn, activated LATS1/2 in association with the adaptor protein MOB, phosphorylate YAP/TAZ ...