| Saturday 4 May 2024 | |
| Events for day: Thursday 29 December 2016 |
| 10:00 - 11:00 Weekly Seminar Clonal Evolution and Relapse in Leukemia School BIOLOGICAL SCIENCES Farmanieh Building, Third Floor, class A. Therapeutic resistance is among the main cause of eventual disease relapse and mortality in cancer patients. During the course of the disease, genetic alterations accumulate following Darwinian evolution. Selective pressure can spur tumor evolution and facilitate the rise of fitter clones. Therapeutic failure is often associated with the natural selection of pre-existing resistant clones, a mechanism shared by blood and solid tumors. Moreover, there is evidence for the rise of small sub-clones harboring differential driver mutations, which gain fitness under therapies that target mutati ... |