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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 9607
School of Cognitive Sciences
  Title:   Effect of intra-amygdala injection of nicotine and GABA receptor agents on anxiety-like behaviour in rats
  Author(s): 
1.  M.R. Zarrindast
2.  Jalal Solati
3.  Shahbanoo Oryan
4.  Kazem Parivar
  Status:   Published
  Journal: PHARMACOLOGY
  Vol.:  82
  Year:  2008
  Pages:   276-284
  Supported by:  IPM
  Abstract:
There is evidence that both cholinergic and GABAergic systems are involved in the neurobiology of anxiety. In the present study, we investigated the effects and interaction of nicotinic and GABAergic systems in the central amygdala of rats, using the elevated plus maze test of anxiety. Bilateral administration of nicotine (1 and 2 u g/rat; 1 u l/rat; 0.5 u l/rat in each side) into the central amygdala (intra-CeA) induced an anxiogenic-like effect, shown by specific decreases in the percentage of open-arm time (

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