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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 8966
School of Cognitive Sciences
  Title:   Effect of Dextromethorphan on Antinociception and Tolerance Induced by Swim-Stress in the Formalin Test
1.  Soheila Fazli-Tabaei
2.  Amir Maghsoudi
3.  Avid Bazaz
4.  Navid Bazaz
5.  Azadeh Modirzadeh
6.  Mohammad-Reza Zarrindast
  Status:   Published
  Journal: Arch Iran Med
  Vol.:  11
  Year:  2008
  Pages:   286-292
  Supported by:  IPM
Background: In the present study, the effect of dextromethorphan on antinociception and tolerance induced by water swim-stress in the formalin test was investigated. Methods: Swim- stress at 8�C induces antinociception in both phases of the formalin test. Intraperitoneal administration of dextromethorphan (60 mg/kg) also induces antinociception in the second phase of the formalin test. The lower doses of dextromethorphan (1.25, 2.5, and 5 mg/kg) which did not induce antinociception alone, but did so in combination with swim- stress (40 second), showed antinociceptive effect in both phases of the test. Exposure to water swimming stress with a period of 20 sec, once daily for three days, altered swim- stress- induced antinociception in the formalin test, when tested on the fourth day. Results: In these animals, exposure to either water swimming stress alone or water swimming stress in combination with dextromethorphan showed potentiation of antinociception induced by swim- stress up to 20 second and decreased the response induced by 40 and 60 second swimstress, indicating a tolerance induction. Dextromethorphan (20 mg/kg) did not alter the changes induced by three days exposure to swim- stress. Conclusion: The results may indicate a possible involvement of n-methyl-d-aspartate receptor mechanism in the antinociception but not tolerance induced by swim- stress at 8�C.

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