• 1
  • 1
  • 2
  • 6
  • 5
  • 6
  • 3
  • 4
IPM
30
YEARS OLD

“School of Cognitive Sciences”

Back to Papers Home
Back to Papers of School of Cognitive Sciences

Paper   IPM / Cognitive Sciences / 8965
School of Cognitive Sciences
  Title:   Ethanol state-dependent memory: Involvement of dorsal hippocampal muscarinic and nicotinic receptors
  Author(s): 
1.  Ameneh Rezayof
2.  Sakineh Alijanpour
3.  Mohammad-Reza Zarrindast
4.  Yassaman Rassouli
  Status:   Published
  Journal: Neurobiology of Learning and Memory
  Vol.:  89
  Year:  2008
  Pages:   441-447
  Supported by:  IPM
  Abstract:
In the present study, the effects of bilateral injections of cholinergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intraperitoneal injection (i.p.) of ethanol (0.25, 0.5 and 1 g/kg) dose dependently induced impairment of memory retention. Pre-test administration of ethanol (0.5 and 1 g/kg, i.p.) induced state-dependent retrieval of the memory acquired under pre-training ethanol (1 g/kg, i.p.) influence. Pre-test intra-CA1 injection of physostigmine (2.5 and 5 lg/mouse, intra-CA1) or nicotine (0.3 and 0.5 lg/mouse, intra-CA1) improved pre-training ethanol (1 g/kg)-induced retrieval impairment. Moreover, pre-test administration of physostigmine (2.5 and 5 lg/mouse, intra- CA1) or nicotine (0.3 and 0.5 lg/mouse, intra- CA1) with an ineffective dose of ethanol (0.25 g/kg) significantly restored the retrieval and induced ethanol statedependent memory. Pre-test intra-CA1 injection of the muscarinic receptor antagonist, atropine (4 and 8 lg/mouse, intra-CA1) or the nicotinic receptor antagonist, mecamylamine (2 and 4 lg/mouse, intra-CA1) 5 min before the administration of ethanol (1 g/kg, i.p.) dose dependently inhibited ethanol statedependent memory. Pre-test intra-CA1 administration of physostigmine (0.5, 2.5 and 5 lg/mouse), atropine (2, 4 and 8 lg/mouse), nicotine (0.1, 0.3 and 0.5 lg/mouse) or mecamylamine (1, 2 and 4 lg/mouse) alone cannot affect memory retention. These findings implicate the involvement of a dorsal hippocampal cholinergic mechanism in ethanol state-dependent memory and also it can be concluded that there may be a cross-state dependency between ethanol and acetylcholine.

Download TeX format
back to top
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
scroll left or right