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IPM
30
YEARS OLD

“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 8957
School of Cognitive Sciences
  Title:   Involvement of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala in anxiety-related behavior
  Author(s): 
1.  Mohammad-Reza Zarrindast
2.  Sahand Babapoor-Farrokhran
3.  Savalan Babapoor-Farrokhran
4.  Ameneh Rezayof
  Status:   Published
  Journal: Life Sciences
  Vol.:  82
  Year:  2008
  Pages:   1175-1181
  Supported by:  IPM
  Abstract:
In the present study, the influence of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala on anxiety-related behaviour was investigated in rats. As a model of anxiety, the elevated plus maze which is a useful test to investigate the effects of anxiogenic or anxiolytic drugs in rodents was used. Bilateral microinjection of different doses of morphine (2.5, 5 and 7.5 μg/rat) into the ventral hippocampus or the nucleus accumbens increased open arm time (not locomotor activity, indicating an anxiolytic response. However, intra-central amygdala administration of the opioid did not show any response. On the other hand, microinjection of a dose of naloxone into the ventral hippocampus (2 μg/rat) or the nucleus accumbens (1 μg/rat) increased open arm time (but not open arm entry (administration of naloxone (0.5, 1 and 2 μg/rat) reversed the anxiolytic effect of morphine (7.5 μg/rat) injected into the ventral hippocampus in a dosedependent manner. A dose of the antagonist (1 μg/rat) also reduced the morphine response (2.5 μg/rat) when injected in the nucleus accumbens. In conclusion, it seems that the opioidergic system in the ventral hippocampus and the nucleus accumbens are involved in anxiety-related behaviors and the ventral hippocampus may be the main site of action of the anxiolytic properties of morphine.

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