“School of Cognitive”

Back to Papers Home
Back to Papers of School of Cognitive

Paper   IPM / Cognitive / 8829
School of Cognitive Sciences
  Title:   Involvement of Amlodipine, Diazoxide, and Glibenclamide in Development of Morphine Tolerance in Mice
  Author(s): 
1.  M.R. Zarrindast
2.  M. Sahebgharani
3.  A. Khalilzadeh
4.  M. Anvari
5.  O. Khalilzadeh
  Status:   Published
  Journal: Int J Neurosci
  Vol.:  118
  Year:  2008
  Pages:   503-18
  Supported by:  IPM
  Abstract:
In this study, the effects of the calcium channel blocker (amlodipine), potassium channel opener (diazoxide), and potassium channel blocker (glibenclamide) on the development of morphine-induced tolerance in the formalin test was investigated. During development of tolerance to morphine, intraperitoneal (i.p.) administration of different doses of amlodipine (5, 7.5 and 10 mg/kg) or diazoxide (1, 5 and 10 mg/kg) in combination with morphine (20 and 30 mg/kg) increased tolerance in the first and second phase of the test. However, glibenclamide (2.5, 5, and 10 mg/kg) decreased morphine tolerance in the second phase of formalin test. It is concluded that calcium and potassium channel mechanisms may be involved in the morphine tolerance.

Download TeX format
back to top
scroll left or right