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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 8587
School of Cognitive Sciences
  Title:   Influence of ATP-sensitive potassium channels on lithium state-dependent memory of passive avoidance in mice
  Author(s): 
1.  M.R. Zarrindast
2.  M. Ebrahimi
3.  A. Khalighzadeh
  Status:   Published
  Journal: EUR J PHARMACOL
  Vol.:  550
  Year:  2006
  Pages:   107-111
  Supported by:  IPM
  Abstract:
The effects of ATP-sensitive potassium channels on lithium induced state-dependent memory of passive avoidance task were examined in mice. The pre-training (5 mg/kg) and pre-test (5 mg/kg) injection of lithium impaired memory retrieval on the test day. Impairment of pre-training lithium was restored by pre-test administration of lithium (5 mg/kg), diazoxide, an ATP-sensitive potassium channel opener, (15, 30 and 60 mg/kg) or glibenclamide, an ATP-sensitive potassium channel blocker, (6 and 18 mg/kg). Pre-test administration of inactive doses of lithium (2.5 and 10 mg/kg) plus lower and inactive dose of glibenclamide (2 mg/kg) or diazoxide (1.5 mg/kg) also reversed the amnesia induced by pre-training lithium (5 mg/kg). In conclusion, the ATP-sensitive potassium channel opener or blocker not only mimicked the effect of lithium in statedependent learning in the absence of lithium on the test day, but also potentiated the effect of low dose of lithium in restoration of memory. Therefore, ATP-sensitive potassium channels may have a modulatory influence on lithium response.

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