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IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 8578
   School of Cognitive Sciences
  Title: The effects of histaminergic agents in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety
  Author(s):
1 . M.R. Zarrindast
2 . M. Torabi
3 . P. Rostami
4 . S. Fazli Tabaei
  Status: Published
  Journal: Pharmacology. Biochemistry and Behavior
  Vol.: 85
  Year: 2006
  Pages: 500-506
  Supported by: IPM
  Abstract:
High levels of histamine are found in the hippocampus. The central histamine system is involved in many physiological behavioural processes including anxiety-related behaviours both in animals and humans. In the present study, we investigated the effects of intra-hippocampal CA1 (intra-CA1) microinjection of histaminergic agents on anxiety-related behaviours in rats, using elevated plus-maze test of anxiety. Intra-CA1 administration of histamine (at the dose of 10 μg/rat) increased open arm time (

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