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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 8578
School of Cognitive Sciences
  Title:   The effects of histaminergic agents in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety
  Author(s): 
1.  M.R. Zarrindast
2.  M. Torabi
3.  P. Rostami
4.  S. Fazli Tabaei
  Status:   Published
  Journal: Pharmacology. Biochemistry and Behavior
  Vol.:  85
  Year:  2006
  Pages:   500-506
  Supported by:  IPM
  Abstract:
High levels of histamine are found in the hippocampus. The central histamine system is involved in many physiological behavioural processes including anxiety-related behaviours both in animals and humans. In the present study, we investigated the effects of intra-hippocampal CA1 (intra-CA1) microinjection of histaminergic agents on anxiety-related behaviours in rats, using elevated plus-maze test of anxiety. Intra-CA1 administration of histamine (at the dose of 10 μg/rat) increased open arm time (

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