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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 8122
School of Cognitive Sciences
  Title:   A Computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus
  Author(s):  A. Hadipour Niktarash
  Status:   Published
  Journal: Journal of Computational Neuroscience
  No.:  3
  Vol.:  20
  Year:  2006
  Pages:   299-320
  Supported by:  IPM
  Abstract:
In Parkinson?s disease, neurons of the internal segment of the globus pallidus (GPi) display the lowfrequency tremor-related oscillations. These oscillatory activities are transmitted to the thalamic relay nuclei. Computer models of the interacting thalamocortical (TC) and thalamic reticular (RE) neurons were used to explore how the TC-RE network processes the low-frequency oscillations of the GPi neurons. The simulation results show that, by an interaction between the TC and RE neurons, the TC-RE network transforms a low-frequency oscillatory activity of the GPi neurons to a higher frequency of oscillatory activity of the TC neurons (the superharmonic frequency transformation). In addition to the interaction between the TCandREneurons, the low-threshold calcium current in the RE and TC neurons and the hyperpolarization-activated cation current (Ih) in the TC neurons have significant roles in the superharmonic frequency transformation property of the TC-RE network. The external globus pallidus (GPe) oscillatory activity, which is directly transmitted to the RE nucleus also displays a significant modulatory effect on the superharmonic frequency transformation property of the TC-RE network.

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