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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 7997
School of Cognitive Sciences
  Title:   Microinjection of ritanserin into the dorsal hippocampal CA1 and dentate gyrus decrease nociceptive behavior in adult male rat
  Author(s): 
1.  E. Soleimannejad
2.  N. Naghdi
3.  S. Semnanian
4.  Y. Fathollahi
  Status:   Published
  Journal: BEHAV BRAIN RES
  No.:  2
  Vol.:  168
  Year:  2006
  Pages:   221-225
  Supported by:  IPM
  Abstract:
Prenatal 5HT depletion causes a significant decrease in the level of nociceptive sensitivity during the second phase of the formalin test behavioral response. These experiments were designed to test whether blocking 5HT2A/2c receptors in the CA1 region of the hippocampus and dentate gyrus would decrease nociceptive behaviors induced by a peripheral noxious stimulus formalin as an animal model of unremitting human being. The 5HT2A/2c receptor antagonist ritanserin (2, 4 and 8 microg/0.5 microl) was injected into the CA1 area and dentate gyrus of behaving rats 5 min before subcutaneous injection of formalin irritant. Nociceptive behaviors in both phases of the formalin test were significantly decreased by ritanserin (4 and 8 microg/0.5 microl) and ritanserin had no effect at 2 microg/0.5 microl. These results support the hypothesis that the hippocampal formation may modify the processing of incoming nociceptive information and that 5HT2A/2c receptor-sensitive mechanisms in the hippocampus may play a role in nociception and/or the expression of related behaviors.

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