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IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 7892
   School of Cognitive Sciences
  Title: Cross state-dependent retrieval between histamine and lithium
  Author(s):
1 . M.R. Zarrindast
2 . S. Fazli-Tabaei
3 . A. Khalilzadeh
4 . M. Farahmanfar
5 . SH. Yahyavi
  Status: Published
  Journal: PHYSIOL BEHAV
  No.: 1-2
  Vol.: 86
  Year: 2005
  Pages: 154-163
  Supported by: IPM
  Abstract:
Histamine and lithium state-dependent (StD) retrieval of passive avoidance task and their interactions was examined in mice. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20 mug/mouse) impaired retrieval when it was tested 24 h later. In the animals, in which retrieval was impaired due to histamine pre-training administration, pre-test administration of histamine, with the same dose, restored retrieval. The H1 blocker, pyrilamine (20 mug/mouse, i.c.v.), but not the H(2) blocker; ranitidine prevented the restoration of retrieval by pre-test histamine. The pre-training (5 and 10 mg/kg) or pre-test (5 mg/kg) injection of lithium also impaired retrieval, when it was tested 24 h later. In the animals that received lithium (5 mg/kg) or histamine (20 mug/mouse) as pre-training treatment, administration of histamine, clobenpropit or lithium, respectively, resulted in restoration of memory retrieval. Neither pyrilamine nor ranitidine prevented the restoration of retrieval by pre-test lithium. In conclusion, histamine or lithium can induce state-dependent retrieval and a cross-StD exists between these drugs, which may be mediated through the inositol pathway.


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