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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 7891
School of Cognitive Sciences
  Title:   Role of the cholinergic system in the rat basolateral amygdala on morphine-induced conditioned place preference
  Author(s): 
1.  M.R. Zarrindast
2.  Z. Fattahi
3.  P. Rostami
4.  A. Rezayof
  Status:   Published
  Journal: Pharmacology. Biochemistry and Behavior
  Vol.:  82
  Year:  2005
  Pages:   1-10
  Supported by:  IPM
  Abstract:
The effects of intra-basolateral amygdala (intra-BLA) injections of physostigmine, atropine, nicotine and/or mecamylamine on morphine-induced conditioned place preference (CPP) in rats was investigated by using an unbiased 3-day schedule of place conditioning design. Animals that received 3 daily injections of morphine (0.5-10 mg/kg) subcutaneously (s.c.) or saline (1.0 ml/kg, s.c.) showed a significant preference for compartment paired with morphine. The maximum response was observed with 7.5 mg/kg of the opioid. Administration of the anticholinesterase drug, physostigmine (1, 3 and 5 mug/rat) with an ineffective dose of morphine (0.5 mg/kg) elicited a significant CPP. Injections of antimuscarinic receptor agent, atropine (1, 4 and 7 mug/rat) dose-dependently inhibited the morphine (7.5 mg/kg)-induced place preference. The injections of nicotine (0.75, 1 and 2 mug/rat) potentiated the morphine (0.5 mg/kg)-induced place preference, while the nicotinic receptor antagonist, mecamylamine (1, 3 and 6 mug/rat) dose-dependently inhibited the morphine (7.5 mg/kg)-induced place preference. Furthermore, administration of atropine (7 mug/rat) but not mecamylamine (6 mug/rat) reduced the response induced by different doses of physostigmine plus morphine. Moreover, mecamylamine (6 mug/rat) but not atropine (7 mug/rat) reduced the response induced by different doses of nicotine plus morphine. It is concluded that the muscarinic and nicotinic receptor mechanisms in the BLA may be involved in the acquisition of morphine-induced place preference.

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