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IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 7852
   School of Cognitive Sciences
  Title: Effect of Vim thalamic DBS in Parkinson's disease on F wave duration
  Author(s):
1 . P. Pakarian
2 . SM. Rayegani
3 . S. Shahzadi
  Status: Published
  Journal: NEUROSCI LETT
  No.: 3
  Vol.: 367
  Year: 2004
  Pages: 323-326
  Supported by: IPM
  Abstract:
F waves were recorded from abductor hallucis muscle in eight Parkinsonian patients with deep brain stimulation (DBS) electrodes surgically implanted in their Vim thalamic nucleus in two conditions of DBS ON and OFF. Patients with relatively anteriorly located electrodes exhibited a significant reduction in F wave duration and also in the UPDRS rigidity score of the corresponding foot when the DBS was ON. In contrast, patients with relatively posteriorly located electrodes exhibited no significant difference in F wave duration in the two DBS ON and OFF conditions. The rigidity UPDRS score in the corresponding foot diminished very little in the latter group. Both groups had great improvement in their tremor at rest UPDRS score in that foot when the DBS was ON. Vim surgery is generally accepted to affect tremor mechanisms. However, surgical intervention in anterior parts of Vim has been reported to affect rigidity mechanisms. This correspondence of these two symptoms of rigidity and tremor with the two locations of anterior and relatively posterior Vim may indicate the contribution of mechanisms of rigidity, but not tremor, in enhancement of F wave duration and hyper excitability of spinal motoneuron.

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