• 1
  • 2
  • 5
  • 6
  • 3
  • 4
IPM
30
YEARS OLD

“School of Cognitive Sciences”

Back to Papers Home
Back to Papers of School of Cognitive Sciences

Paper   IPM / Cognitive Sciences / 7850
School of Cognitive Sciences
  Title:   Involvement of nucleus accumbens in L-arginine-induced conditioned place preference in rats
  Author(s): 
1.  H. Sahraei
2.  G. Pirzadeh-Jahromi
3.  M. Noorbakhshnia
4.  A. Asgari
5.  A. Haeri-Rohani
6.  A. Khoshbaten
7.  GR. Poorheidari
8.  H. Sepehri
9.  H. Ghoshooni
10.  MR. Zarrindast
  Status:   Published
  Journal: Behavioral Pharmacology
  No.:  7
  Vol.:  15
  Year:  2004
  Pages:   473-480
  Supported by:  IPM
  Abstract:
In the present study, the effects of intraperitoneal, intra-accumbal and intra-ventral tegmental area administration of L-arginine and N(G)-nitro-L-arginine methyl-ester (L-NAME) on conditioned place preference behavior were studied. Intraperitoneal (i.p.; 0.5, 1 and 5 mg/kg) and intra-accumbal (intra-NAc; 0.3, 1 and 3 microg/rat), but not intra-ventral tegmental area (intra-VTA; 0.3, 1 and 3 microg/rat) administrations of L-arginine produced a significant place conditioning. Similar injections of L-NAME did not produce any response. However, intraperitoneal pretreatment of the animals with L-NAME (5, 10 and 20 mg/kg), 30 min before L-arginine administration, significantly abolished the acquisition of place conditioning induced by either intraperitoneal or intra-accumbal injection of L-arginine. Moreover, injection of L-NAME (5, 10 and 20 mg/kg) on the test day did not alter the L-arginine response. The results may indicate that L-arginine induces conditioned place preference via an increase in nitric oxide (NO) in the nucleus accumbens.

Download TeX format
back to top
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
scroll left or right