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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 7848
School of Cognitive Sciences
  Title:   The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice
  Author(s): 
1.  H. Sahraei
2.  M. Falahi
3.  M.R.. Zarrindast
4.  M. Sabetkasaei
5.  M. H. Ghoshooni
6.  M. Khalili
  Status:   Published
  Journal: EUR J PHARMACOL
  No.:  1-3
  Vol.:  503
  Year:  2004
  Pages:   81-87
  Supported by:  IPM
  Abstract:
In the present study, the possible role of nitric oxide on the conditioned place preference (CPP) induced by nicotine in mice was investigated. Intraperitoneal (i.p.) injections of nicotine (1 mg/kg) and the nitric oxide (NO) precursor, L-arginine (200 and 500 mg/kg), produced significant place preference. However, injection of mecamylamine (0.05 and 0.1 mg/kg; i.p.) or the NO synthase (NOS) inhibitor, L-Nitro-amino-methyl-ester, L-NAME (5-20 mg/kg; i.p.), had no effect. Ineffective doses of nicotine in combination with ineffective doses of L-arginine produced significant place preference. Administration of L-arginine (50, 100 and 150 mg/kg; i.p.) on the test day reduced the expression of nicotine-induced place preference. Nicotine injection (0.25, 0.5 and 0.75 mg/kg) on the test day reduced the expression of place preference induced by L-arginine, while both mecamylamine (0.05 and 0.1 mg/kg) and L-NAME (5, 10 and 20 mg/kg) inhibited the acquisition of place preference induced by nicotine (1 mg/kg) and L-arginine (200 mg/kg). Moreover, neither of the antagonists reduced the expression of nicotine- or L-arginine-induced place preference. It is suggested that nitric oxide may play an important role in nicotine-induced place preference

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