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Paper   IPM / Particles And Accelerator / 16671
School of Particles and Accelerator
  Title:   Dosimetric effect of nanoparticles in the breast cancer treatment using INTRABEAM(R) system with spherical applicators in the presence of tissue heterogeneities: A Monte Carlo study
  Author(s): 
1.  Eyachew Misganew Tegaw
2.  Ghazale Geraily
3.  Seyed Mohsen Etesami
4.  Hossein Ghanbari
5.  Somayeh Gholami
6.  Mehdi Shojaei
7.  Mostafa Farzin
8.  Getu Ferenji Tadesse
  Status:   Published
  Journal: Biomedical Phys. & Engineering Express
  No.:  035017
  Vol.:  7
  Year:  2021
  Supported by:  IPM
  Abstract:
Using the 50 kV INTRABEAM® IORT system after breast-conserving surgery: tumor recurrence and organs at risk (OARs), such as the lung and heart, long-term complications remain the challenging problems for breast cancer patients. So, the objective of this study was to address these two problems with the help of high atomic number nanoparticles (NPs). A Monte Carlo (MC) Simulation type EGSnrc C++ class library (egspp) with its Easy particle propagation (Epp) user code was used. The simulation was validated against the measured depth dose data found in our previous study (Tegaw, et al 2020 Dosimetric characteristics of the INTRABEAM ® system with spherical applicators in the presence of air gaps and tissue heterogeneities, Radiat. Environ. Biophys. (10.1007/s00411-020-00835-0)) using the gamma index and passed 2

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