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Paper   IPM / Cognitive Sciences / 16555
School of Cognitive Sciences
  Title:   Temporal dynamics of animacy categorization in the brain of patients with mild cognitive impairment
  Author(s): 
1.  H. Karimi
2.  H. Marefat
3.  C. Kalafatis
4.  H. Modarres
5.  Z. Vahabi
6.  S. Khaligh-Razavi
7.  M. Khanbagi
  Status:   Preprint
  Journal: bioRxiv
  Year:  2021
  Supported by:  IPM
  Abstract:
Electroencephalography (EEG) has been commonly used to measure brain alterations in Alzheimer’s Disease (AD). However, reported changes are limited to those obtained from using univariate measures, including activation level and frequency bands. To look beyond the activation level, we used multivariate pattern analysis (MVPA) to elicit the pattern of information processing from EEG responses to an animacy categorization task. Comparing healthy controls (HC) with patients with mild cognitive impairment (MCI), we found that the neural speed of animacy information processing is decreased in MCI patients. Moreover, we found critical time-points during which the representational pattern of animacy for MCI patients was significantly discriminable from that of HC, while the activation level remained unchanged. Together, these results suggest that the speed and pattern of animacy information processing provide clinically useful information as a potential biomarker for detecting early changes in MCI and AD patients.
Competing Interest Statement SKR and CK serve as the chief scientific officer and the chief medical officer at Cognetivity Neurosciences ltd.. All the other authors declare no competing interest.


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