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Paper   IPM / Cognitive Sciences / 16380
School of Cognitive Sciences
  Title:   Investigation of the programmed cell death by encapsulated cytoskeleton drug liposomes using a microfluidic platform
  Author(s): 
1.  Z. Vaezi
2.  M. Sedghi
3.  M. Ghorbani
4.  S. Shojaeilangari 
5.  A. Allahverdi
6.  H. Naderi-Manesh
  Status:   Published
  Journal: Microfluidics and Nanofluidics
  Vol.:  24
  Year:  2020
  Supported by:  IPM
  Abstract:
The low membrane permeability of lipophilic drugs was resolved using liposomes as a solubilizing agent and the precise size control of them is a significant parameter in drug carrier technology. Here, we have established a microfluidic octanol-assisted liposome assembly method to produce a surfactant-assisted liposome which has merged by the cytoskeleton drug (Taxotere) encapsulation in a single process step, then a complete microfluidic cellular analysis was performed in trapping cell device with an optofluidic assay for quantifying drug permeability. The optimization of process variables resulted in the formation of liposomes with particle size 6.75 ± 0.5 µm and monodispersity 6.2


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