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IPM
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“School of Biological Sciences”

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Paper   IPM / Biological Sciences / 16067
School of Biological Sciences
  Title:   A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimers disease
  Author(s): 
1 . Saeedeh Hosseinian
2 . Ehsan Arefian
3 . Hassan Rakhsh-Khorshid
4 . Mehdi Eivani
5 . Ameneh Rezayof
6 . Hamid Pezeshk
7 . Sayed-Amir Marashi
  Status:   Published
  Journal: Scientific Reports
  No.:  1
  Vol.:  10
  Year:  2020
  Pages:   1-9 https://doi.org/10.1038/s41598-020-64452-z
  Supported by:  IPM
  Abstract:
Since the world population is ageing, dementia is going to be a growing concern. Alzheimers disease is the most common form of dementia. The pathogenesis of Alzheimers disease is extensively studied, yet unknown remains. Therefore, we aimed to extract new knowledge from existing data. We analysed about 2700 upregulated genes and 2200 downregulated genes from three studies on the CA1 of the hippocampus of brains with Alzheimer�??s disease. We found that only the calcium signalling pathway enriched by 48 downregulated genes was consistent between all three studies. We predicted miR-129 to target nine out of 48 genes. Then, we validated miR-129 to regulate six out of nine genes in HEK cells. We noticed that four out of six genes play a role in synaptic plasticity. Finally, we confirmed the upregulation of miR-129 in the hippocampus of brains of rats with scopolamineinduced amnesia as a model of Alzheimers disease. We suggest that future research should investigate the possible role of miR-129 in synaptic plasticity and Alzheimers disease. This paper presents a novel framework to gain insight into potential biomarkers and targets for diagnosis and treatment of diseases.


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