• 1
  • 1
  • 2
  • 6
  • 5
  • 6
  • 3
  • 4
IPM
30
YEARS OLD

“School of Cognitive Sciences”

Back to Papers Home
Back to Papers of School of Cognitive Sciences

Paper   IPM / Cognitive Sciences / 15920
School of Cognitive Sciences
  Title:   Effect of rat parental morphine exposure on passive avoidance memory and morphine conditioned place preference in male offspring
  Author(s): 
1.  A. Akbarabadi
2.  S. Niknamfar
3.  N. Vousooghi
4.  M. Sadat-Shirazi
5.  H. Toolee
6.  M. Zarrindast
  Status:   Published
  Journal: Physiology & Behavior
  Vol.:  184
  Year:  2018
  Pages:   143-149
  Supported by:  IPM
  Abstract:
Drug addiction is a chronic disorder resulted from complex interaction of genetic, environmental, and developmental factors. Epigenetic mechanisms play an important role in the development and maintenance of addiction and also memory formation in the brain. We have examined passive avoidance memory and morphine conditioned place preference (CPP) in the offspring of male and/or female rats with a history of adulthood morphine consumption. Adult male and female animals received chronic oral morphine for 21 days and then were maintained drug free for 10 days. After that, they were let to mate with either an abstinent or control rat. Male offspring's memory was evaluated by step through test. Besides, rewarding effects of morphine were checked with CCP paradigm. Offspring of abstinent animals showed significant memory impairment compared to the control group which was more prominent in the offspring of abstinent females. Conditioning results showed that administration of a high dose of morphine (10 mg/kg) that could significantly induce CPP in control rats, was not able to induce similar results in the offspring of morphine abstinent parents; and CPP was much more prominent when it was induced in the offspring of morphine exposed females compared to the progeny of morphine exposed males. It is concluded that parental morphine consumption in adulthood even before mating has destructive effects on memory state of the male offspring and also leads to tolerance to the rewarding effects of morphine. These effects are greater when the morphine consumer parent is the female one.

Download TeX format
back to top
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
scroll left or right