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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 15911
School of Cognitive Sciences
  Title:   Component-related BOLD response to localize epileptic focus using simultaneous EEG-fMRI recordings at 3T
  Author(s): 
1.  E. Ebrahimzadeh
2.  H. Soltanian-Zadeh
3.  B. NadjarAraabi
4.  S. HashemiFesharaki
5.  J. MehvariHabibabadi
  Status:   Published
  Journal: Journal of Neuroscience Methods
  Vol.:  322
  Year:  2019
  Pages:   34-49
  Supported by:  IPM
  Abstract:
Background Simultaneous EEG-fMRI experiments record spatiotemporal dynamics of epileptic activity. A shortcoming of spike-based EEG-fMRI studies is their inability to provide information about behavior of epileptic generators when no spikes are visible.
New method We extract time series of epileptic components identified on EEG and fit them with Generalized Linear Model (GLM) model. This allows a precise and reliable localization of epileptic foci in addition to predicting generator's behavior. The proposed method works in the source domain and delineates generators considering spatial correlation between spike template and candidate components in addition to patient's medical records.
Results The proposed method was applied on 20 patients with refractory epilepsy and 20 age- and gender-matched healthy controls. The identified components were examined statistically and threshold of localization accuracy was determined as 86
Comparison with existing methods We compared the proposed method with conventional methods. Our comparisons showed superiority of the proposed method. In particular, when epileptogenic zone was located deep in the brain, the method outperformed existing methods.
Conclusions This study contributes substantially to increasing the yield of EEG-fMRI and presents a realistic estimate of the neural behavior of epileptic generators, to the best of our knowledge, for the first time in the literature.

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