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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 15906
School of Cognitive Sciences
  Title:   Reversible inactivation of interpeduncular nucleus impairs memory consolidation and retrieval but not learning in rats: A behavioral and molecular study
1.  L. Khatami
2.  F. Khodagholi
3.  F. Motamedi
  Status:   Published
  Journal: Behavioural Brain Research
  Vol.:  342
  Year:  2018
  Pages:   79-88
  Supported by:  IPM
The Interpedundular nucleus (IPN) is a small midbrain structure located deeply between the two cerebral peduncles. The strategic placement of this nucleus makes it a possible relay between structures involved in the modulation of hippocampal theta rhythm activity. In this study we aimed to investigate how reversible inactivation of IPN could affect the acquisition, consolidation and retrieval phases of memory in passive avoidance (PA) and Morris water maze (MWM) tasks. To support our data, molecular studies were performed in order to detect possible changes in the expression of proteins related to learning and memory in the hippocampus. To address this issue rats' IPN was reversibly inactivated by microinjection of lidocaine hydrochloride (4

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