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IPM
30
YEARS OLD

“School of Nano-Sciences”

Paper   IPM / Nano-Sciences / 15876
   School of Nano Science
  Title: Protein corona impact on nanoparticle-cell interactions: Toward an energy-based model of endocytosis
  Author(s):
1 . P. Shadmani
2 . B. Mehrafrooz
3 . Abbas Montazeri
4 . R. Naghdabadi
  Status: To Appear
  Journal: J. Physics: Condens. Matter
  Supported by: IPM
  Abstract:
Upon incubation of nanoparticles in biological fluids, a new layer called as protein corona is formed on their surface affecting the interactions between nano particles and targeted cell during the endocytosis process. In the present study,a mathematical model based on the diffusion of membrane mobile receptors is proposed. Opposing the endocytosis proceeding, membrane bending and tension energies are named as resistant energy. Also, binding energy and free-energy associated with the configurational entropy are called as promoter energy. Utilizing this model, endocytosis of gold nanoparticle (GNP) is simulated to explore the biological media effect. The results reveal that there exists a nanoparticle size of 60nm at which, the endocytosis time is minimum. It has been illustrated that, although for sufficiently small particles of diameter 30nm, membrane tension has a negligible contribution (< 10endocytosis time but also can lead to incomplete engulfment by decreasing the ligand density on the nanoparticle surface. Use of the proposed model can play a significant role in advancing the design of nanoparticles in the targeted drug delivery applications.

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