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IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 15491
   School of Cognitive Sciences
  Title: Prefrontal Cortex Represents Long-Term Memory of Object Values for Months
  Author(s):
1 . A. Ghazizadeh
2 . S. Hong
3 . O. Hikosaka
  Status: Published
  Journal: Current Biology
  Vol.: 28
  Year: 2018
  Pages: 2206-2217
  Supported by: IPM
  Abstract:
As a central hub for cognitive control, prefrontal cortex (PFC) is thought to utilize memories. However, unlike working or short-term memory, the neuronal representation of long-term memory in PFC has not been systematically investigated. Using single-unit recordings in macaques, we show that PFC neurons rapidly update and maintain responses to objects based on short-term reward history. Interestingly, after repeated object-reward association, PFC neurons continue to show value-biased responses to objects even in the absence of reward. This value-biased response is retained for several months after training and is resistant to extinction and to interference from new object-reward learning for many complex objects (>90). Accordingly, the monkeys remember the values of the learned objects for several months in separate testing. These findings reveal that in addition to flexible short-term and low-capacity memories, primate PFC represents stable long-term and high-capacity memories, which could prioritize valuable objects far into the future.

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