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Paper   IPM / Biological / 15141
School of Biological Sciences
  Title:   Molecular evolution and phylodynamics of hepatitis B virus infection circulating in Iran
1.  Sayed-Hamidreza Mozhgani
2.  Seyed Amir Malekpour
3.  Mehdi Norouzi
4.  Fatemeh Ramezani
5.  Seyed Abdolrahim Rezaee
6.  Vahdat Poortahmasebi
7.  Mehdi Sadeghi
8.  Seyed Moayed Alavian
9.  Mohadeseh Zarei-Ghobadi
10.  Azam Ghaziasadi
11.  Hadi Karimzadeh
12.  Reza Malekzadeh
13.  Masood Ziaee
14.  Farshid Abedi
15.  Behrooz Ataei
16.  Majid Yaran
17.  Babak Sayad
18.  Hamid Reza Jahantigh
19.  Mohammad hossein Somi
20.  Gholamreza Sarizadeh
21.  Ismail Sanei-Moghaddam
22.  Fariborz Mansour-Ghanaei
23.  Hossein Keyvani
24.  Ebrahim Kalantari
25.  Zahra Fakhari
26.  Babak Geravand
27.  Seyed Mohammad Jazayeri
  Status:   Published
  Journal: Archive of Virology
  Year:  2018
  Pages:   1-10
  Supported by:  IPM
Previous local and national Iranian publications indicate that all Iranian hepatitis B virus (HBV) strains belong to HBV genotype D. The aim of this study was to analyze the evolutionary history of HBV infection in Iran for the first time, based on an intensive phylodynamic study. The evolutionary parameters, time to most recent common ancestor (tMRCA), and the population dynamics of infections were investigated using the Bayesian Monte Carlo Markov chain (BMCMC). The effective sample size (ESS) and sampling convergence were then monitored. After sampling from the posterior distribution of the nucleotide substitution rate and other evolutionary parameters, the point estimations (median) of these parameters were obtained. All Iranian HBV isolates were of genotype D, sub-type ayw2. The origin of HBV is regarded as having evolved first on the eastern border, before moving westward, where Isfahan province then hosted the virus. Afterwards, the virus moved to the south and west of the country. The tMRCA of HBV in Iran was estimated to be around 1894, with a 95

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