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IPM
30
YEARS OLD

“School of Biological Sciences”

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Paper   IPM / Biological Sciences / 15126
School of Biological Sciences
  Title:   DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism
  Author(s): 
1.  Ali Sharifi-Zarchi
2.  Daniela Gerovska
3.  Kenjiro Adachi
4.  Mehdi Totonchi
5.  Hamid Pezeshk
6.  Ryan Taft
7.  Hans Schöler
8.  Hamidreza Chitsaz
9.  Mehdi Sadeghi
10.  Hossein Baharvand
11.  Marcos Araúzo-Bravo
  Status:   Published
  Journal: BMC Genomics
  No.:  1
  Vol.:  18
  Year:  2017
  Pages:   964
  Supported by:  IPM
  Abstract:
DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between DNA methylation and H3K4me1, a chromatin hallmark of enhancers.

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