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IPM
30
YEARS OLD

“School of Biological Sciences”

Paper   IPM / Biological Sciences / 15126
   School of Biological Sciences
  Title: DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism
  Author(s):
1 . Ali Sharifi-Zarchi
2 . Daniela Gerovska
3 . Kenjiro Adachi
4 . Mehdi Totonchi
5 . Hamid Pezeshk
6 . Ryan Taft
7 . Hans Schöler
8 . Hamidreza Chitsaz
9 . Mehdi Sadeghi
10 . Hossein Baharvand
11 . Marcos Araúzo-Bravo
  Status: Published
  Journal: BMC Genomics
  No.: 1
  Vol.: 18
  Year: 2017
  Pages: 964
  Supported by: IPM
  Abstract:
DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between DNA methylation and H3K4me1, a chromatin hallmark of enhancers.

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