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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 14754
School of Cognitive Sciences
  Title:   Resting state networks as simultaneously measured with fMRI and PET.
1.  A. Savio
2.  S. Funger
3.  M. Tahmasian
4.  S. Rachakonda
5.  A. Manoliu
6.  C. Sorg
7.  T. Grimmer
8.  V. Calhoun
9.  A. Drzezga
10.  V. Riedl
11.  I. Yakushev
  Status:   Published
  Journal: The Journal of Nuclear Medicine
  Year:  2017
  Pages:   1-17
  Supported by:  IPM
Functional magnetic resonance imaging (fMRI) studies reported disruption of resting-state networks (RSNs) in a number of neuropsychiatric disorders. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) captures neuronal activity that is in steady state at a longer time span and is less dependent of neuro-vascular coupling. Here, we aimed to identify RSNs in FDG-PET data and compare their spatial pattern with those obtained from simultaneously acquired resting state fMRI data in 22 middle-aged healthy subjects. Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair to moderate for the default mode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities. The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting state connectivity in PET data.

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