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IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 14726
   School of Cognitive Sciences
  Title: Two-Photon Na + Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites
  Author(s):
1 . T. Jodar
2 . N. Gerkau
3 . S. Aghvami
4 . C. Rose
5 . V. Egger
  Status: Published
  Journal: Frontiers in Cellular Neuroscience
  Vol.: 11
  Year: 2017
  Pages: 1-11
  Supported by: IPM
  Abstract:
Dendrodendritic synaptic interactions are a hallmark of neuronal processing in the vertebrate olfactory bulb. Many classes of olfactory bulb neurons including the principal mitral cells (MCs) and the axonless granule cells (GCs) dispose of highly efficient propagation of action potentials (AP) within their dendrites, from where they can release transmitter onto each other. So far, backpropagation in GC dendrites has been investigated indirectly via Ca2+ imaging. Here, we used two-photon Na+ imaging to directly report opening of voltage-gated sodium channels due to AP propagation in both cell types. To this end, neurons in acute slices from juvenile rat bulbs were filled with 1 mM SBFI via whole-cell patch-clamp...

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