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“School of Biological Sciences”

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Paper   IPM / Biological Sciences / 14595
School of Biological Sciences
  Title:   Testis-Specific Y-Centric Protein–Protein Interaction Network Provides Clues to the Etiology of Severe Spermatogenic Failure
  Author(s): 
1.  Naser Ansari-Pour
2.  Zahra Razaghi Moghadam
3.  Farnaz Barneh
4.  Mohieddin Jafari
  Status:   Published
  Journal: Journal of proteome research
  No.:  3
  Vol.:  15
  Year:  2016
  Pages:   1011-1022
  Supported by:  IPM
  Abstract:
Pinpointing causal genes for spermatogenic failure (SpF) on the Y chromosome has been an ever daunting challenge with setbacks during the past decade. Since complex diseases result from the interaction of multiple genes and also display considerable missing heritability, network analysis is more likely to explicate an etiological molecular basis. We therefore took a network medicine approach by integrating interactome (protein–protein interaction (PPI)) and transcriptome data to reconstruct a Y-centric SpF network. Two sets of seed genes (Y genes and SpF-implicated genes (SIGs)) were used for network reconstruction. Since no PPI was observed among Y genes, we identified their common immediate interactors. Interestingly, 81

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