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IPM
30
YEARS OLD

“School of Biological Sciences”

Paper   IPM / Biological Sciences / 14185
   School of Biological Sciences
  Title: SIREN Cytoscape plugin: Interaction Type Discrimination in Gene Regulatory Networks
  Author(s):
1 . J. Montojo.
2 . P. Khosravi.
3 . V. H. Gazestani.
4 . G. D. Bader.
  Status: Published
  Journal: arXiv
  Year: 2015
  Pages: arXiv preprint arXiv:1512.05067
  Supported by: IPM
  Abstract:
Integrating expression data with gene interactions in a network is essential for understanding the functional organization of the cells. Consequently, knowledge of interaction types in biological networks is important for data interpretation. Signing of Regulatory Networks (SIREN) plugin for Cytoscape is an open-source Java tool for discrimination of interaction type (activatory or inhibitory) in gene regulatory networks. Utilizing an information theory based concept, SIREN seeks to identify the interaction type of pairs of genes by examining their corresponding gene expression profiles. We introduce SIREN, a fast and memory efficient tool with low computational complexity, that allows the user to easily consider it as a complementary approach for many network reconstruction methods. SIREN allows biologists to use independent expression data to predict interaction types for known gene regulatory networks where reconstruction methods do not provide any information about the nature of their interaction types. The SIREN Cytoscape plugin is implemented in Java and is freely available at this http URL and via the Cytoscape app manager.

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