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IPM
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YEARS OLD

“School of Biological”

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Paper   IPM / Biological / 13640
School of Biological Sciences
  Title:   Evolutionary solution for RNA design problem
  Author(s): 
1 . A. Esmaili-Taheri.
2 . M. Ganjtabesh.
3 . M. Mohammad Noori.
  Status:   Published
  Journal: Bioinformatics
  Year:  2014
  Pages:   1-9
  Supported by:  IPM
  Abstract:
RNAs play fundamental roles in cellular processes.The function of an RNA is highly dependent on its 3D conformation, which is referred to as the RNA tertiary structures. Because the prediction or experimental determination of these structures is difficult , so many works focus on the problems associated with the RNA secondary structure. Here, we consider the RNA inverse folding problem, in which an RNA secondary structure is given as a target structure and the goal is to design an RNA sequence that folds into the target structure. In this article, we introduce a new evolutionary algorithm for the RNA inverse folding problem. Our algorithm, entitled Evolutionary RNA Design, generates a sequence whose minimum free energy structure is the same as the target structure.

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