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“School of Nano-Sciences”

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Paper   IPM / Nano-Sciences / 13518
School of Nano Science
  Title:   Modelling the effect of a GHz electric field on the dynamics of K1 ions in KcsA potassium channel
  Author(s): 
1 . M. Sajadi
2 . Amir Lohrasebi
3 . Hashem Rafii Tabar
  Status:   Published
  Journal: Molecular Simulation
  No.:  5
  Vol.:  40
  Year:  2014
  Pages:   399-407
  Publisher(s):   Taylor & Francis
  Supported by:  IPM
  Abstract:
The dynamics of potassium ions in a KcsA channel, located within a stochastically fluctuating medium, is modelled via the application of the molecular dynamics simulation method. We investigate the effect of presence and absence of an applied electric field, either constant or periodic, on the dynamics of the channel. It is found that the ions undergo a hopping motion when the channel is exposed to a constant electric field of strength 0.03 V/nm. Furthermore, an alternating electric field in the GHz range, normally present in the daily environment and encountered by most biological systems, is applied to the channel, showing that in this frequency range, the rigidity of the atomic bonds of the filter is increased, which in turn disturbs the ionic passage rate through the filter. Consequently, in this frequency range, the application of electric fields may affect the function of such channels.

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