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IPM
30
YEARS OLD

“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 13226
School of Cognitive Sciences
  Title:   Involvement of the dorsal hippocampal dopamine D2 receptors inhistamine-induced anxiogenic-like effects in mice
  Author(s): 
1.  M. Piri
2.  E. Ayazi
3.  M.R. Zarrindast
  Status:   Published
  Journal: Neuroscience Letters
  Vol.:  550
  Year:  2013
  Pages:   139-144
  Supported by:  IPM
  Abstract:
Anxiety-related behaviors increase histamine and dopamine release in the brain. On the other hand, central histamine counteracts reward and reinforcement processes mediated by the mesolimbic dopamine system. We investigated the effects of the histaminergic system and dopamine D2 receptors agents and their interactions on anxiety-related behaviors using the elevated plus-maze (EPM). The intra-hippocampal (Intra-CA1) microinjection of histamine (10 μg/mouse) decreased the percentage of open arm time (

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