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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 13225
School of Cognitive Sciences
  Title:   Suggesting a possible role of CA1 histaminergic system inharmane-induced amnesia
1.  M. Nasehi
2.  E. Mashaghi
3.  F. Khakpai
4.  M.R. Zarrindast
  Status:   Published
  Journal: Neuroscience Letters
  Vol.:  556
  Year:  2013
  Pages:   5-9
  Supported by:  IPM
A number of tremorogenic -carboline alkaloids such as harmane are naturally present in the humanfood chain. They are derived from medicinal plants such as Peganum harmala that have been used as folkmedicine in anticancer therapy. In the present study, effects of the histaminergic system of the dorsal hip-pocampus (CA1) on harmane-induced amnesia were examined. One-trial step-down was used to assessmemory retention in adult male mice. The results showed that pre-training intra-CA1 administrationof histamine (5 g/mouse), ranitidine (H2receptor antagonist; at the doses of 0.25 and 0.5 g/mouse)and pyrilamine (H1receptor antagonist; at the dose of 5 g/mouse) decreased memory formation. Pre-training intraperitoneal (i.p.) administration of harmane (12 mg/kg) also decreased memory formation.Moreover, pre-training intra-CA1 injection of a sub-threshold dose of histamine (2.5 g/mouse) couldreverse harmane (12 mg/kg, i.p.)-induced impairment of memory. On the other hand, pre-training intra-CA1 injection of sub-threshold doses of ranitidine (0.0625 g/mouse) and pyrilamine (2.5 g/mouse)increased harmane-induced impairment of memory. In conclusion, the present findings suggest theinvolvement of the CA1 histaminergic system in harmane-induced impairment of memory formation.

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