“School of Biological”
Back to Papers HomeBack to Papers of School of Biological
| Paper IPM / Biological / 13213 |
|
||||
| Abstract: | |||||
|
Hidden Markov models are widely used in Bioinformatics. They are applied to protein sequence alignment, protein family annotation and gene-finding.The Baum-Welch training is an expectation-maximization algorithm for training the emission and transition probabilities of hidden Markov models. For very long training sequence, even the most efficient algorithms are memory-consuming. In this paper we discuss different approaches to decrease the memory use and compare the performance of different algorithms. In addition, we propose a bidirection algorithm with linear memory. We apply this algorithm to simulated data of protein profile to analyze the strength and weakness of the algorithm.
Download TeX format |
|||||
| back to top | |||||
