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Paper   IPM / Cognitive Sciences / 13199
School of Cognitive Sciences
  Title:   The involvement of dorsal hippocampus in dextromethorphan-induced state-dependent learning in mice
1.  M.R. Zarrindast
2.  V. Ownegh
3.  A. Rezayof
4.  F. Ownegh
  Status:   Published
  Journal: Pharmacology, Biochemistry and Behavior
  Vol.:  116
  Year:  2014
  Pages:   90-95
  Supported by:  IPM
In an effort to understand the effect of dextromethorphan (DM; 3-methoxy-17-methylmorphinan), a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptors on memory retrieval, male NMRI mice received intraperitoneal (i.p.) or intra-CA1 injection of this drug before or after training and before testing in passive avoidance task. Pre-training i.p. (20 mg/kg) or intra-CA1 (0.5 and 1 μg/mouse) administration of DM induced amnesia in a dose-dependent manner. Post-training i.p. (10 and 20 mg/kg) or intra-CA administration of DM (0.5 and 1 μg/mouse) however, did not affect the memory retrieval. Moreover, memory retrieval was impaired in animals receiving either i.p. (20 mg/kg) or intra-CA1 administration of DM (0.5 and 1 μg/mouse) prior to testing, suggesting the DM-induced amnesia. Interestingly, the amnestic effect of pre-training i.p. (20 mg/kg) or intra-CA1 administration of DM (1 μg/mouse) was restored in mice receiving pre-test i.p. (5 and 10 mg/kg) or intra-CA1 (0.25 and 0.5 μg/mouse) administration of the drug, indicating DM-induced state-dependent learning. Taken together, it can be concluded that DM administration impairs memory retrieval in a dose- and time-dependent manner. Moreover, DM can induce state-dependent learning. Dorsal hippocampus appears to play an important role upon DM influence of learning and memory processes.

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