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IPM
30
YEARS OLD

“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 13198
School of Cognitive Sciences
  Title:   Effects of dopamine receptor agonist and antagonists on cholestasis-induced anxiolytic-ike behaviors in rats
  Author(s): 
1.  M.R. Zarrindast
2.  D. Eslimi Esfahani
3.  S. Oryan
4.  M. Nasehi
5.  M. Torabi Nami
  Status:   Published
  Journal: European Journal of Pharmacology
  Vol.:  702
  Year:  2013
  Pages:   25-31
  Supported by:  IPM
  Abstract:
Dysfunctions in the dopamine transmission system have been suggested to contribute to the pathogenesis of hepatic encephalopathy. In an experimental animal model, cholestasis induction through bile duct ligation may present several main pathological features of hepatic encephalopathy. Dopaminergic systems are shown to play pivotal roles in regulation of anxiety-like behaviors. The main bile duct in male Wistar rats, weighing 220–240 g, was ligated using two ligatures plus duct transection in between. Anxiety-like behaviors were measured using the elevated plus maze task. Cholestasis increased the open arm time percentage (

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