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Paper   IPM / Biological / 13165
School of Biological Sciences
  Title:   Discovering domain mediating protein interactions
  Author(s):  Changiz
  Status:   Published
  No.:  11
  Vol.:  1
  Year:  2013
  Pages:   22-31
  Supported by:  IPM
Background: Protein-protein interactions do not provide any direct information re-garding the domains within the proteins that mediate the interactions. The majority ofproteins are multi domain proteins and the interaction between them is often definedby the pairs of their domains. Most of the former studies focus only on interacting do-main pairs. However they do not consider the interactions that require the presence ofa third domain.Objectives: In this manuscript, we define the concept of necessary and sufficient tripletsof domains and mediator domain.Materials and Methods: We approximate these conditions by pragmatic statistical defi-nitions on a set of gold-standard interacting protein pairs and a set of gold-standardnon-interacting protein pairs.Results: In this paper we introduce a new method for the prediction of the interactionbetween two domains using third domains as a mediator.we show that the mediatordomain has an effective role in the interaction between proteins.Conclusions: By using these concepts, we introduce a method for the prediction of theinteraction between two domains. Subsequently by evaluating the performance of ourmethod on the yeast protein interactions data set, we show that the mediator domainhas an effective role in the interaction between proteins

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