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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 13102
School of Cognitive Sciences
  Title:   Anxiolytic-like effect induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in the rat amygdala is mediated through the D1 and D2 dopaminergic systems
  Author(s): 
1.  M.R. Zarrindast
2.  S. mahboodi
3.  M.S. Sadat Shirazi
4.  S. Ahmadi
  Status:   Published
  Journal: Journal of Psychopharmacology
  Vol.:  25
  Year:  2011
  Pages:   131-140
  Supported by:  IPM
  Abstract:
In the present study the influence of the dopaminergic system(s) of the amygdala on the anxiolytic-like effect of the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in male Wistar rats was investigated. An elevated plus-maze test of anxiety was used to assess anxiety-like behaviors. The results showed that bilateral intra-amygdala injections of ACPA (0.125, 1.25 and 5�??ng/rat) and the mixed dopamine D1/D2 receptor agonist, apomorphine, at different doses (0.001, 0.01 and 0.1�??µg/rat) increased percentage open arm time (

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