• 3
  • 3
  • 82
  • 82
IPM
30
YEARS OLD

“School of Cognitive Sciences”

Paper   IPM / Cognitive Sciences / 12825
   School of Cognitive Sciences
  Title: Scopolamine induced memory impairment; possible involvement of NMDA receptor mechanisms of dorsal hippocampus and/or septum
  Author(s):
1 . Fatemeh Khakpai,
2 . Mohammad Nasehi
3 . Ali Haeri-Rohani
4 . Akram Eidi
5 . Mohammad Reza Zarrindast
  Status: Published
  Journal: Behavioural Brain Research
  Vol.: 231
  Year: 2012
  Pages: 1-10
  Supported by: IPM
  Abstract:
Background and aim: The anatomical connections of septum and hippocampus and the influence of cholinergic and glutamatergic projections in these sites have been reported. In the present study, the effect of pre-training intra-dorsal hippocampal (CA1) and intra-medial septal (MS) administration of scopolamine, a nonselective muscarinic acetylcholine antagonist, and NMDA receptor agents and their interactions, on acquisition of memory have been investigated. Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions and in the medial septum. Animals were trained in a step-through type inhibitory avoidance task, and tested 24 h after training to measure step-through latency as memory retrieval. Results: Intra-CA1 or intra-MS injections of scopolamine (0.5, 1 and 2 µg/rat) and D-AP7 (a competitive NMDA receptor antagonist; 0.025, 0.05 and 0.1 µg/rat) reduced, while NMDA (0.125 and 0.25 µg/rat) increased memory. Intra-MS injection of a subthreshold dose of NMDA reduced scopolamine induced amnesia in the MS. However, similar injection of NMDA into CA1 did not alter scopolamine response when injected into CA1. Moreover, intra-MS or -CA1 injection of a subthreshold dose of NMDA did not alter scopolamine response in the CA1 or MS respectively. On the other hand, co-administration subthreshold doses of D-AP7 and scopolamine into CA1 and/or MS induced amnesia. Conclusions: The cholinergic system between septum and CA1 are modulating memory acquisition processes induced by glutamatergic system in the CA1 or septum and co-activation of these systems in these sites can influence learning and memory.

Download TeX format
back to top
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
scroll left or right