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IPM
30
YEARS OLD

“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 12814
School of Cognitive Sciences
  Title:   Dopaminergic system in CA1 modulates MK-801 induced anxiolytic-like responses
  Author(s): 
1.  Mohammad Reza Zarrindast
2.  Mohammad Nasehi
3.  Mahnaz Pournaghshband
4.  Batool Ghorbani Yekta
  Status:   Published
  Journal: Pharmacology, Biochemistry and Behavior
  Vol.:  103
  Year:  2012
  Pages:   102-110
  Supported by:  IPM
  Abstract:
Rationale: Today, there is relatively no debate on the notion that NMDA receptor antagonist agents in the hippocampus induce anxiolytic-like effects through distinct mechanisms. There is also a bulk of studies showing the involvement of the dopaminergic system in NMDA induced behaviors. Thus, on the basis of the involvement of dopaminergic system in anxiety-related behaviors, the present study aimed to investigate the involvement of the dorsal hippocampal (CA1) dopaminergic system in anxiolytic-like responses induced by MK801 (NMDA receptor antagonist) in maleWistar rats. Methods: We used the elevated plus maze to test anxiety. This apparatus has widely been employed to test parameters of anxiety-related behaviors including the open armtime percentage (

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